The trailer follows Doug (Jack Black) and Griff (Paul Rudd), longtime pals who decide to remake their childhood favorite film Anaconda. They gather a crew, head into the Amazon, but chaos ensues when the real danger appears: a giant anaconda, unexpected financing chaos, snake rentals gone wrong, and survival suddenly becomes more than just art. The mood shifts fast from comedy about midlife crises to action-horror as what was supposed to be fun becomes a fight for life. The trailer leans into meta humor, creature threats, and absurd situations wrapped in jungle adventure.